Not known Facts About mif
Not known Facts About mif
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The crystal constructions in the MIF-inhibitor complexes were being made use of because the initial templates for virtual screening. The Protein Preparation Wizard module in Schrödinger was used to organize Each and every MIF elaborate. The ligand located within the Energetic web page involving chains A and B was taken care of. The advanced was then refined with the OPLS drive industry [26]. Pro1, an essential nucleophilic residue, was protonated In line with experimental and theoretical final results [27].
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